Banca de DEFESA: JULIE ANNE PEREIRA CAVALCANTE

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : JULIE ANNE PEREIRA CAVALCANTE
DATE: 28/03/2023
TIME: 09:00
LOCAL: Programa de Pós-Graduação em Ciência de Materiais
TITLE:

DESIGN OF A BIOPOLYMER SYSTEM BACTERIAL CELLULOSE MEMBRANE AND MICRONEEDLE  WITH METHOTREXATE RELEASE FOR DERMATOLOGICAL APPLICATIONS

KEY WORDS:

Transdermal. Methotrexate. Bacterial cellulose. Microneedles.

PAGES: 95
BIG AREA: Outra
AREA: Multidisciplinar
SUMMARY:

Due to the complexity and high cost of treatment, some dermatological diseases are not treated by patients, as in the case of psoriasis, which affects millions of people around the world. This pathology follows different therapies with medications administered topically, orally and parenterally. However, they have problems in all three forms. And so, transdermal administration of methotrexate, the main drug for psoriasis and other dermatological pathologies, avoids the negative effects of other routes and increases efficacy. Thus, it is important to have a matrix for incorporating the drug, as well as an agent to overcome the corneal barrier of the skin. Thus, in this work, a transdermal delivery system of methotrexate was developed with a biopolymeric matrix of bacterial cellulose membrane, which has been used on a large scale for medical applications due to its relevant properties, and with polymeric microneedles of carboxymethylcellulose, as a physical agent for overcome the skin barrier and the release of the drug by this route is efficient. Analyzes were carried out Optical Microscopy (OM), Scanning Electron Microscopy (SEM), Infrared Spectroscopy (FTIR), Thermogravimetry (TGA), X-Ray Diffraction (DRX), swelling test, mechanical compression test and insertion of in vitro skin, cytotoxicity test and in vitro drug release assay. The incorporation of MTX, by the mechanical method, was successful in the CB/MTX bacterial cellulose membrane, with confirmation from the FTIR, XRD and SEM analyses. The BC membrane incorporated with MTX (BC/MTX) and the complete system (BC/MTX/MN) showed similar thermal stability. The membrane with MTX (BC/MTX) showed satisfactory morphology, with morphological aspects of both materials. The microneedle (MN) showed good mechanical resistance for insertion into the skin and good swelling quality. The BC/MTX/MN system showed controlled release of the drug. Finally, the system produced showed potential for future application in the biomedical sector, with relevant biological properties, such as biocompatibility, mechanical resistance, dissolution and good delivery of the drug to the skin, being a good material for use in different dermatological diseases, with good adhesion and low cost.

COMMITTEE MEMBERS:
Externo à Instituição - MARCOS VINICIUS DA SILVA PAULA - UFPA
Presidente - 1354207 - SEVERINO ALVES JUNIOR
Interna - 1283002 - YEDA MEDEIROS BASTOS DE ALMEIDA