Banca de QUALIFICAÇÃO: DÁRIO CÉSAR DE OLIVEIRA CONCEIÇÃO

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : DÁRIO CÉSAR DE OLIVEIRA CONCEIÇÃO
DATE: 02/03/2023
LOCAL: Programa de Pós-Graduação em Ciência de Materiais
TITLE:

Synthesis and Characterization of Hollow Magnetite and Cobalt Ferrite Nanospheres for Biomedical Applications.

KEY WORDS:

Nanospheres; Cobalt Ferrite; Magnetite; Biomedical Applications.

PAGES: 58
BIG AREA: Outra
AREA: Multidisciplinar
SUMMARY:

Magnetic nanoparticles have aroused great interest in biomedical applications due to their characteristics, such as their size in relation to cellular structures and their ability to respond to magnetization gradients. Medical applications range from use as contrast agents to drug-loaded structures. This study aims to synthesize and characterize spherical, hollow and mesoporous nanoparticles of cobalt ferrite, CoFe2O4 and Magnetite, Fe3o4, for biomedical applications as a drug carrier system, biosensor and for treatment using hyperthermia. The synthesis of the particles was carried out by the solvothermal method assisted by Cetyltrimethylammonium bromide, which acts as a directing agent, creating mesopores in the nanoparticles. The characterization of the morphology of the particles was verified by Scanning Electron Microscopy, observing the formation of spheres. The characterization of the chemical composition and crystalline structure by X-Ray Diffraction revealed the formation of an inverted spinel structure, characteristic for cobalt and magnetite ferrite materials. The analysis carried out with Spectroscopy in the Infrared Region with Fourier Transform (FTIR) revealed a signal around 580 cm-1, which corresponds to the characteristic of the connection between metal and oxygen in the structure with ferrite and magnetite that is perceived due to vibration of the crystalline phase, thus confirming the diffraction data. The drug absorption assay allowed verifying the efficiency of the nanoparticle in relation to the storage capacity. The continuity of the work will focus on the optimization of the nanoparticle synthesis route, followed by the finalization of the characterization. The potential as a drug carrier, as a biosensor and the ability to act in relation to the use of hyperthermia will also be investigated, as well as the properties related to cytotoxicity. The possibility of chemical changes in the drug caused by interactions between the nanospheres will also be investigated.

COMMITTEE MEMBERS:
Externo ao Programa - 2281129 - ALEXANDRE RICALDE RODRIGUES - nullPresidente - 2572606 - GLORIA MARIA VINHAS
Externa ao Programa - 1836797 - ROSA AMALIA FIREMAN DUTRA - null