Banca de QUALIFICAÇÃO: ALISSON SILVA DE ALBUQUERQUE

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : ALISSON SILVA DE ALBUQUERQUE
DATE: 30/01/2023
LOCAL: Programa de Pós-Graduação em Ciência de Materiais
TITLE:
KEY WORDS:

microneedles; printable nanocomposite; biomedical applications; stereolithography.

PAGES: 146
BIG AREA: Outra
AREA: Multidisciplinar
SUMMARY:

Vaccination is considered one of the most significant health interventions for controlling infectious diseases. Despite advances, transdermal delivery systems are not yet well established for vaccine delivery, which would be ideal since the skin is the largest organ in the human body and allows for controlled drug delivery. However, transdermal drug delivery has only been used for a small group of drugs, as most compounds cannot pass through the skin at therapeutic rates. The extraordinary barrier properties of the stratum corneum, the outermost part of the skin, allow only certain molecules, such as low molecular weight or lipophilic drugs, to pass through. The skin's very low permeability can be circumvented with the use of microneedles, which are pointed microstructures designed to break through the skin to reach the dermal microcirculation, allowing the delivery of macromolecules and vaccines painlessly and safely. Additive manufacturing provides versatile, simple, highly reproducible, and accurate solutions on a micrometric scale for the manufacturing of microneedles in a fast, reliable, and economical way. This work presents a proposal for the production and characterization of printable microneedles with active material, bioinspired in the microstructures of urticating hairs of Urtica dioica (L.). For this, some actions are being executed: the first involves the development of a printable and biocompatible polymeric nanocomposite with self-decontaminating action of the printed surfaces. The nanometric phase of this composite, formed by silver nanoparticles produced in doped bioglasses, crushed, and mixed in printable resin, gives bactericidal properties to the material. Multi-walled carbon nanotubes may constitute another nanometric phase of the composite, aiming to form nanoneedles, forming hierarchical structures in size (nanoneedles on bioinspired microneedles). To orient these nanotubes, an electric field was applied, and it was possible to align them. From this proof of concept, it is intended to orient them during printing to obtain the nanoneedles on the printed surfaces. In another action, a biocompatible resin is being developed jointly with LASOM/DQF/UFPE, which will be used as the polymeric phase of the nanocomposites in the printing of the bioinspired microneedles. Toxicity tests of the commercial resins and prepared nanocomposites were performed, in collaboration with FIOCRUZ PE (Instituto Aggeu Magalhães), which indicated the samples with cell viability. The printed topologies were also characterized, and roughness information was obtained, including biomimetic microtexturing, which allowed to evaluate the resolution limit of the printers.

COMMITTEE MEMBERS:
Presidente - 1167723 - ARMANDO JUAN NAVARRO VAZQUEZ
Externa ao Programa - 1134731 - NORMA BUARQUE DE GUSMAO - nullExterno ao Programa - 1133947 - SILVIO DE BARROS MELO - null