Banca de QUALIFICAÇÃO: EDIELEN FRANÇA DOS SANTOS

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : EDIELEN FRANÇA DOS SANTOS
DATE: 22/07/2022
LOCAL: Programa de Pós-Graduação em Ciência de Materiais
TITLE:

DEVELOPMENT OF POLYMER-BASED MICRONEEDLES FOR TRANSDERMAL USE IN DERMATOLOGICAL DISEASES

KEY WORDS:

Polymeric Microneedles. Keloid. 3D printing. Alginate. Polymethylmethacrylate.

PAGES: 87
BIG AREA: Outra
AREA: Multidisciplinar
SUMMARY:

Keloids are a fibroproliferative disease that results from an abnormal wound healing process. It is responsible for psychosocial disorders due to aesthetic problems and functional disability, which reduces the quality of life of affected individuals. Due to their unknown etiopathogenesis, timely treatment is still a major challenge. For this, the strategy in the development of microneedles using additive manufacturing technology for 3D printing enables simple and low-cost prototyping. In this sense, the present work aimed to develop a therapeutic agent, polymeric microneedles, through the combination of 3D printing and micromolding, as a carrier of the drugs dexamethasone and quercetin in the treatment of keloids. The master microneedles were designed and 3D printed, for subsequent micromolding in thermoplastic adhesive and production of polymeric microneedles made of alginate and polymethylmethacrylate. The alginate matrix showed insufficient fracture toughness, requiring additives to improve mechanical strength; in this perspective, the alginate was combined with metallogels (MOGs) to form interpenetrating networks (IPN), where their respective characterizations are in progress. Regarding the PMMA microneedle matrices analyzed by optical microscopy and scanning electron microscopy, they presented themselves satisfactorily in the submillimeter range with good straightness and a high degree of detail. However, they presented low resolution of the tips and porous surface structures; the latter implies the mechanical properties, but it was presented as a fundamental criterion in the process of drug adsorption. Bearing in mind that some adjustments need to be refined in order to obtain polymeric microneedle matrices with good mechanical properties and cutting edge resolution, the 3D printing and micromolding method used in this work show promising results with potential for use as drug delivery systems in the keloid treatment.

BANKING MEMBERS:
Externa à Instituição - DAYANE KELLY DIAS DO NASCIMENTO - UFPE
Externo à Instituição - EMANOEL LAURERTAN TAVARES FRANÇA - UFPE
Externo à Instituição - LEONIS LOURENÇO DA LUZ - UFPE