Banca de QUALIFICAÇÃO: FELLYPE DIORGENNES CORDEIRO GOMES

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : FELLYPE DIORGENNES CORDEIRO GOMES
DATE: 14/09/2023
LOCAL: PROGRAMA DE PÓS-GRADUAÇÃO EM CIÊNCIA DE MATERIAIS
TITLE:

DESIGN OF MOF'S OF GALLIUM: FROM ANTIMICROBIAL ACTIVITY TO BONE NEOFORMATION

KEY WORDS:

Metal-Organic Framework. Gallium. Silver Nanoparticles. Gallium Prussian Blue analog nanoparticle. Periodontitis. MG-63 cells.

PAGES: 103
BIG AREA: Outra
AREA: Multidisciplinar
SUMMARY:

Periodontitis is an inflammatory condition that affects the dental support tissues, triggered by an infection caused by periodontal pathogenic biofilm. The host's inflammatory-immune responses to periodontal microorganisms are responsible for the tissue damage observed in this pathology, including periodontal attachment loss and bone tissue loss. However, the lack of medications that can stimulate bone neoformation and effectively combat microorganisms makes periodontitis treatment a significant challenge in dentistry. This study describes the development of Gallium Metal-Organic Frameworks (MOFs). The objective is to prepare and characterize Ga-MIL-116 MOF, Ga-MIL-116@AgNPs MOF composite, and GaPBNPs (Gallium Prussian Blue analog) MOF with PVP (Polyvinylpyrrolidone) and Chelating Agent. Several characterization techniques were used, such as X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), ultraviolet-visible spectroscopy (UV-Vis), thermogravimetric analysis (TGA), and scanning electron microscopy (SEM). The analyses confirmed the presence of silver nanoparticles in GaMIL-116 and the formation of GaPBNPs, in which the XRD technique allowed calculating the crystallite sizes of 12 nm and 25 nm for GaPBNPs-PVP and GaPBNPs-Chelating, respectively. Additionally, biological tests were conducted using MG-63 osteoblast-like cells to evaluate cell viability. The results showed that the Ga-MIL-116@AgNPs composite caused a decrease in cell viability at concentrations of 6, 12, 25, 50, and 100 µg/ml, while the GaPBNPs did not show any decrease. Overall, the results indicate that the Ga-MIL-116@AgNPs composite and GaPBNPs developed in this research show potential for future studies related to bone neoformation, becoming a promising approach for advanced periodontal treatments.

COMMITTEE MEMBERS:
Externo à Instituição - Deoclecio Ferreira de Brito - UEPB
Externa à Instituição - Iêda Maria Garcia dos Santos - UFPB
Presidente - 2457389 - EDUARDO PADRON HERNANDEZ