Banca de DEFESA: ANNA LUISA ARAUJO BRITO

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : ANNA LUISA ARAUJO BRITO
DATE: 28/03/2024
TIME: 14:00
LOCAL: Virtual
TITLE:

Assessment of Late Effects of SARS-CoV-2 Exposure on Respiratory, Osteomuscular, and Functional Functions in Individuals in the Agreste of Pernambuco.

KEY WORDS:

Coronavirus Infections; SARS-CoV-2; Respiratory Function Tests; Diagnostic Techniques, Respiratory System; Muscle Strength; Physical Functional Performance

PAGES: 70
BIG AREA: Ciências da Saúde
AREA: Fisioterapia e Terapia Ocupacional
SUMMARY:

INTRODUCTION: A part of the COVID-19 survivor population reports persistent symptoms, despite the long period after the acute phase of the disease, which reinforces the need for a multidimensional assessment of respiratory, musculoskeletal and functional function. OBJECTIVE: To evaluate the late effects of exposure to SARS-COV-2 on respiratory, musculoskeletal and functional functions in individuals in rural Pernambuco. METHODS: This is an observational and cross-sectional study approved by the Human Research Ethics Committee of the Federal University of Pernambuco (4.666.483) and registered with Clinical Trials (NCT05659615) involving individuals in post-COVID-19 conditions. Sociodemographic, anthropometric, clinical data and multidimensional assessment of respiratory function were collected using variables from the ventilometry, respiratory diagnostic assistant (RDA), manovacuometry and spirometry instruments. Peripheral muscle strength was measured using the Medical Research Council and handgrip dynamometer, and cardiorespiratory performance was assessed using the 6-minute walk test. Data collection was carried out from May to October 2022. RESULTS: In total, 92 post-COVID-19 individuals were analyzed, with a majority of 67.4% being female. The average age was 27.79 ± 10.76 years, with an average body mass index of 25.92 ± 5.17 kg/m². Participants were classified according to convalescence time, with 50 (54.4%) within the range of 1 to 12 weeks and 42 (45.6%) between 13 and 24 months. When stratified by period of convalescence, significant differences were observed in the respiratory rate, measured by the ventilator (p = 0.028), and in the slow vital capacity (ml/kg), measured by the RDA (p = 0.043), although these have no implications evident clinics. Regardless of the time since symptom onset, all 83 (100%) individuals assessed for slow vital capacity by the RDA showed a reduction in relation to predicted values, while 74% showed a decrease in forced expiratory volume in one second (FEV1) and 65% at maximum inspiratory pressure (PImax) (p <0.005). No significant differences were observed in the variables of peripheral muscle function and functional capacity. CONCLUSION: Despite late exposure to COVID-19, individuals showed residual changes in respiratory function, regardless of convalescence time. Although no statistically significant differences were identified between the groups stratified by time, nor in relation to musculoskeletal function and functional capacity, it is essential to incorporate a multidimensional assessment to define therapeutic goals and monitor interventions more precisely and effectively.

COMMITTEE MEMBERS:
Presidente - 1900364 - SHIRLEY LIMA CAMPOS
Interna - 2581397 - DANIELLA CUNHA BRANDAO
Externa ao Programa - 3344367 - BRUNA THAYS SANTANA DE ARAUJO - UFPE