Banca de DEFESA: PAULA ARARUNA BERTAO

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : PAULA ARARUNA BERTAO
DATE: 19/07/2022
TIME: 09:00
LOCAL: Pós-Graduação em Ciências da Saúde
TITLE:

ASSOCIATION BETWEEN CARDIOTOXICITY RISK AND ELECTROCARDIOGRAPHIC FINDINGS IN PATIENTS SUBMITTED TO ANTHRACYCLINE CHEMOTHERAPY.

KEY WORDS:

cardiotoxicity; anthracycline; electrocardiogram; QTc; global longitudinal strain; GLS.

PAGES: 91
BIG AREA: Ciências da Saúde
AREA: Medicina
SUMMARY:

Introduction: Anthracycline chemotherapy treatment is associated with cardiotoxicity. Echocardiography is a useful tool in the detection of early myocardial injury. The electrocardiogram still has no established role in this scenario. Objective: To analyze the association between electrocardiographic changes and the development of subclinical cardiotoxicity in cancer patients undergoing treatment with anthracycline. Methods: Prospective cohort of cancer patients treated with anthracycline. Transthoracic echocardiograms with global longitudinal strain and electrocardiogram were performed before the start of treatment, at 3 and 6 months of follow-up to assess the presence or absence of subclinical cardiotoxicity, defined by a relative drop in global longitudinal strain greater than 15% in relation to the initial measurement. on at least one echocardiogram. Fisher's exact test was applied to assess this association. Results: Of the 33 patients included (mean age = 49 ± 9.5 years), 23 had breast cancer. Eight (24.24%) had incipient cardiotoxicity. QTc in women was higher than baseline at 6 months by both Bazett and Fridericia (p = 0.011 and p =0.038, respectively). There was an association, in women, between QTc > 460ms (corrected by Bazett) at 3 months and a drop in global longitudinal strain >15% in this period (p=0.043). Conclusion: The presence of QTc > 460ms at 3 months in women was associated with subclinical cardiotoxicity.

BANKING MEMBERS:
Presidente - 587939 - BRIVALDO MARKMAN FILHO
Interno - 1984024 - MARCELO RENATO GUERINO
Externo ao Programa - 3346536 - SANDRO GONCALVES DE LIMA
Externa ao Programa - 5315871 - SIMONE CRISTINA SOARES BRANDAO