EXPLORING METALLIC NANOPARTICLES IN BIOMEDICAL THERMAL APPLICATIONS.
Optical therapy. Metallic nanoparticles. Thermoplasmonics.
Optical techniques has become an integral part of progress in biomedical sciences and several areas of medicine such as oncology, physiotherapy, urology, cardiology and ophthalmology, where its use for diagnostic and therapeutic purposes is widely known. The physical properties of light can be extensively applied to developing tools and strategies that can be explored to treat diseases and advance point-of-care testing, promoting research and well being. Optical therapies such as Photodynamic Therapy (PDT) and Photothermal Therapy (PTT) has been employed in the control of microbial infections. PDT combines the use of photosensitizing agents and light to induce localized and selective damage to cells and tissues, while PTT is based on light-mediated temperature increase to thermally induce localized cell death. In this sense, the use of metallic nanoparticles (NPs) has emerged in recent years, in which the localized surface plasmon resonance (LSPR) phenomena is exploited as an alternative for high performance photosensitizers, enhancing light absorption and achieving tissue temperature control. In this Thesis Project, we propose the use of optimized plasmonic gold nanorods and nanospheres to enhance the performance of optical therapies related to thermal phenomena and investigate their effects in different applications. Previous results shows that a size-dependent approach can be applied to maximize the thermal performance of metallic nanoparticles, which may lead to the reduction of the nanoparticle dose administered in plasmon-based thermal therapies.