Banca de DEFESA: JOSÉ HÉLIO LUNA DA SILVA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : JOSÉ HÉLIO LUNA DA SILVA
DATE: 15/02/2023
TIME: 18:30
LOCAL: GOOGLE MEET
TITLE:
KEY WORDS:

Antibodies; COVID-19; Professionals; Health; Vaccine.

PAGES: 84
BIG AREA: Ciências da Saúde
AREA: Nutrição
SUMMARY:

COVID-19 (Coronavirus Disease-19) is a disease caused by the RNA virus called SARS-CoV-19 (Severe Acute Respiratory Syndrome CoronaVirus 2). Although most people develop mild or moderate forms of COVID-19, approximately 5-15% develop the severe form of the disease. Healthcare workers are at increased risk of contracting SARS-CoV-2 infection. The immunization of these professionals becomes one of the key pieces for the control of the pandemic. This has set off a real race in vaccine development, with over 200 vaccines being tested as of November 2020. The traditional process that involves vaccine development is a rather slow process. The pandemic demanded rapid action in developing a vaccine on a timescale never seen before. Some questions remain under investigation, such as those related to general effectiveness or effectiveness in specific groups; type of immunity (sterile or not); and duration of immunity. Therefore, the objective of this study was to quantify the titers of specific immunoglobulins against SARS-CoV-2 in vaccinated health professionals in Vitória de Santo Antão-PE and to assess their association with sociodemographic and/or exposure factors. The present study took place in the municipality of Vitória de Santo Antão-PE and had the participation of professionals who were directly linked to the Municipal Health Department and in professional practice. Serological collections were carried out between 03/16/2021 to 05/04/2021, the first took place before receiving the vaccine and the second after receiving the immunizer (post-vaccine collection took place between 19 and 79 days after administration of the immunizing agent), for further serological analysis in the Molecular Biology laboratory of the Centro Acadêmico de Vitória by means of the enzyme immunoassay using the immunosorbent assay (ELISA). Reference values were classified as negative when the antibody ratio was <0.8, inconclusive ≥0.8 to <1.1, and positive when the ratio was ≥1.1. Twenty (20) individuals aged between 22 and 54 years old (mean 33.2±8.5 years old) participated in the research. After vaccination, 95% (n=19) of the participants were producing specific immunoglobulins against SARS-CoV-2 and only 1 individual was inconclusive after receiving both doses of the immunizer. An increase in post-vaccination antibody titers was found when compared to pre-vaccination titers for all occupations. A statistical difference was found in the IgG levels of individuals who reported having symptoms before administration of the immunizer when compared to those who did not. No statistical difference was found by age group and no correlation was observed between IgG titers and the interval of days between the second dose of the immunizer and post-vaccination collection.

COMMITTEE MEMBERS:
Presidente - 1806262 - MARIANE CAJUBA DE BRITTO LIRA NOGUEIRA
Externa ao Programa - 2298916 - IDJANE SANTANA DE OLIVEIRA - UFPEExterno à Instituição - REGINALDO CORREIA DA SILVA FILHO