Banca de DEFESA: ROXANA PATRÍCIA BEZERRA DA SILVA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : ROXANA PATRÍCIA BEZERRA DA SILVA
DATE: 24/02/2023
TIME: 14:30
LOCAL: GOOGLE MEET
TITLE:



KEY WORDS:
“environmental enrichment”; “serotonergic system”; "social isolation"; "anxiety"; "depression".

PAGES: 125
BIG AREA: Ciências da Saúde
AREA: Nutrição
SUMMARY:
Social isolation (SI), particularly when it occurs in early stages of development, is related to adverse  neurobehavioral effects and neurochemical changes, especially when it occurs in the first instance of development. On the other hand, environmental enrichment (EE) appears to reduce anxiety- and depression-like behaviors, as well as increase serotonin levels in the prefrontal cortex and hippocampus in rodents. The aim of this study was to systematically review the effects of social isolation and environmental enrichment on emotional behavior and some components of the serotonergic system in rats after weaning. Two authors performed a blind search in electronic databases Medline/PubMed, LILACS, Scopus, Web of Science, EMBASE and Sigle via Open Gray. The first stage of the searches consisted of reading the articles by title and abstract. Subsequently, the articles were read in full. Studies included in this review were primary experimental studies that subjected rats to IS, EA and normal social conditions after weaning. The quality of the selected studies was assessed considering the recommendations of SYRCLE's Risk of Bias. The Kappa index was calculated to measure the degree of agreement between reviewers during the article selection stage, as well as in the study quality assessment stage. The results showed that animals exposed to EA had lower body weight, improved behavioral habituation index and improved coping response to situations of uncontrollable stress. In addition, the enriched environment produced antidepressant effects and promoted an increase in the amount of serotonin in the hippocampus and prefrontal cortex of rodents. In addition, the enriched environment reduced depression-like behavior and promoted an increase in the amount of serotonin in the hippocampus and prefrontal cortex of rodents. Thus, environmental stimuli during the critical period of development were associated with better emotional response as well as higher levels of serotonin in brain regions in the long term. 

COMMITTEE MEMBERS:
Externa à Instituição - EDUARDA CORREIA MORETTI - UFAL
Presidente - 2936085 - KELLI NOGUEIRA FERRAZ PEREIRA ALTHOFF
Interna - 2447615 - LIGIA CRISTINA MONTEIRO GALINDO
Notícia cadastrada em: 25/01/2023 11:28
SIGAA | Superintendência de Tecnologia da Informação (STI-UFPE) - (81) 2126-7777 | Copyright © 2006-2024 - UFRN - sigaa11.ufpe.br.sigaa11