Banca de DEFESA: JÉSSICA ANDRESA BEZERRA DA SILVA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : JÉSSICA ANDRESA BEZERRA DA SILVA
DATE: 14/02/2023
TIME: 18:00
LOCAL: GOOGLE MEET
TITLE:
KEY WORDS:
Health Care Professionals; SARS-CoV-2; Antibodies; Immunoglobulin A; Immunoglobulin G.

PAGES: 110
BIG AREA: Ciências da Saúde
AREA: Nutrição
SUMMARY:
Since the beginning of the pandemic, health professionals have become one of the main risk groups for SARS-CoV-2 infection and the scientific community seeks to understand the immunological kinetics of exposure to the virus in order to know how long the responses last. of antibodies are maintained, or whether they will provide protection against re-infection. The objective of this study was to analyze the kinetics of anti-SARS-CoV-2 IgA and IgG antibodies in health professionals symptomatic for COVID-19 in the municipality of Vitória de Santo Antão, Pernambuco. This is a descriptive and analytical study, with a longitudinal design, carried out with health professionals working on the front lines of the fight against COVID-19 and who had any symptom associated with the flu syndrome. Data collection was through the Individual Registration Form - Cases of Severe Acute Respiratory Syndrome Hospitalized made available by the Municipal Health Department and serological samples were collected in the months of June, July and October 2020. The results of the serum levels of IgA and Anti-SARS-CoV-2 IgG were obtained by the immunoenzymatic ELISA test and arranged in ascending order based on the interval of days and weeks between the date of onset of symptoms and the date of serological collection for laboratory analysis. The minimum and maximum intervals between the onset of symptoms and collection were 10 and 212 days. The sample consisted of 21 health professionals, aged between 26 and 50 years (± 38.1 years), 12 (57.1%) belonged to the nursing professional category and obesity was the most prevalent condition, followed by hypertension, diabetes and asthma. Symptoms such as headache, anosmia, asthenia, ageusia, fever and myalgia were commonly reported at the onset of the disease and characterize the manifestations of the mild form of COVID-19. Positive IgA antibodies were detected in a minimum interval of 10 days with a subsequent decline over the second and third collections, similar to the dynamics of the humoral immune response in SARS-CoV viral infections. Some participants had increased serum IgA levels, which could be attributed to instances of reinfection or an IgA antibody response to other coronavirus genera. Furthermore, positive IgA antibody levels were detectable for approximately seven months, probably corresponding to a new feature of the manifestation of humoral immunity in response to SARS-CoV-2 infection. IgG antibodies were also detected early in the disease with a subsequent increase throughout the second and third collections, similar to the humoral immune response of the SARS-CoV virus. Positive anti-SARS-CoV-2 IgG titers remained detectable for approximately 7 months, contributing to immunological memory. The study made it possible to identify a heterogeneity in the magnitude of the responses and it is still unclear for how long the antibodies will promote protective immunity against secondary infection of SARS-CoV-2, suggesting the continuity of the analyzes, with different immunological targets and also incorporating the responses against the artificial inductions of immunity, such as vaccines.

COMMITTEE MEMBERS:
Externo à Instituição - FABIO MARCEL DA SILVA SANTOS - UFPB
Presidente - 2936085 - KELLI NOGUEIRA FERRAZ PEREIRA ALTHOFF
Interno - 1340604 - THYAGO MOREIRA DE QUEIROZ
Notícia cadastrada em: 24/01/2023 13:27
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