Banca de QUALIFICAÇÃO: JÉSSICA ANDRESA BEZERRA DA SILVA

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : JÉSSICA ANDRESA BEZERRA DA SILVA
DATE: 30/06/2022
LOCAL: GOOGLE MEET
TITLE:
KEY WORDS:

professionals; health; coronavirus; Antibodies.

PAGES: 72
BIG AREA: Ciências da Saúde
AREA: Nutrição
SUMMARY:

The coronavirus disease 2019 (COVID-19) caused by the SARS-CoV-2 virus has caused a worldwide Public Health Emergency. The disease transmitted through respiratory droplets, eliminated by coughing and sneezing, infects people of all ages and causes different clinical manifestations. The rapid spread of the disease, causing overcrowding of public health services and direct exposure to infected patients, made health professionals working on the front line, one of the populations at greatest risk for infection. The use of serological tests helps in the identification of acute or previous SARS-CoV-2 infection, from the detection of specific antibodies to the virus. The response of IgA and IgG antibodies against SARS-CoV-2 has been shown to be highly heterogeneous among individuals, and longer follow-up is important for the construction of kinetics. Thus, this work aims to study the kinetics of IgA and IgG anti-SARS-CoV-2 antibodies in symptomatic health professionals for COVID-19 in the municipality of Vitória de Santo Antão, Pernambuco. The study was developed through the collection of serological samples in the months of June, July and October 2020 at the Municipal Health Department of Vitória de Santo Antão, with subsequent analysis of the antibodies in the Laboratory of Microbiology and Immunology of the Academic Center of Vitória, through the enzyme immunoassay ELISA, being classified as negative when the proportions of antibodies were < 0.8, indeterminate between 0.8 to 1.0 and positive ≥ 1.1. The titers of IgA and IgG antibodies obtained after the serological analysis were organized in ascending order based on the interval of days between the date of onset of symptoms and the date of serological collection for laboratory analysis. The interval of days was subdivided for analysis of the kinetics of IgA and IgG antibodies, in: 10 to 30, 10 to 45, 10 to 60, 10 to 90, 10 to 120, 10 to 150 and 10 to 212 days. Fifty-two anti-SARS-CoV-2 antibody samples from 20 healthcare professionals were evaluated at different time intervals. In the results, 21 health professionals participated with a mean age of 38.1 years (SD±7.89) and more than half (57.1%) belonged to the professional nursing category, the most reported symptoms were headache (85 .7%), loss of smell and asthenia (81%). Different IgA and IgG antibody responses against SARS-CoV-2 were observed after the onset of symptoms. Positive IgA levels did not present a statistically significant correlation at different time intervals, however, a statistically significant correlation was observed between positive IgG levels and time in the intervals between 10 to 120 and 10 to 150 days. After 212 days, irregular antibody behavior and high levels of positive IgG were observed, however, there was no statistically significant correlation in IgG levels and time in this interval.

BANKING MEMBERS:
Externa ao Programa - 2067644 - ANA LISA DO VALE GOMES
Externo ao Programa - 1569173 - JOSE CANDIDO DE SOUZA FERRAZ JUNIOR
Presidente - 2936085 - KELLI NOGUEIRA FERRAZ PEREIRA ALTHOFF