“environmental enrichment”; “serotonergic system”; "social isolation"; "anxiety"; "depression".
Social isolation (SI) is related to the neurobehavioral effects of development, particularly when they occur in early neurochemical developmental situations. Furthermore, enrichment (EA) appears to have behavioral patterns related to anxiety and depression, as well as increasing serotonin levels in the prefrontal cortex and hippocampus in rodents. The aim of this study will be to systematically review the environmental isolation systems, body weight, food intake and components of the serotonergic system in terms of early social isolation. Two authors blind search in electronic databases Medline/PubMed, LILACS, Scopus, Web of Science, EMBASE and Sigle via Open Gray. Primary experimental studies that sub-measured rats to IS, EA and normal condition after weaning were included in this review. The quality of the studies was selected from the SYRCLE Risk of Bias. The Kappa index was calculated to measure the degree of AE agreement between the review results. of serotonin in the hippocampus and prefrontal cortex. In this way, the EA seems to reverse the changes in behavior or rights by the IS.