Banca de DEFESA: TAIANE DE LIMA SILVA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : TAIANE DE LIMA SILVA
DATE: 30/06/2023
TIME: 09:00
LOCAL: https://meet.google.com/mzw-khxe-nrb
TITLE:

Effects of alpha-tocopherol and tempol on cardiac autonomic modulation in rats submitted to intrauterine malnutrition: the role of oxidative stress and Na⁺ and Ca²⁺ transporting ATPases

KEY WORDS:

Alfa-tocoferol; ATPases cardíacas; desnutrição intrauterina; tempol; variabilidade cardíaca.

PAGES: 67
BIG AREA: Ciências da Saúde
AREA: Nutrição
SUMMARY:

The relationship between chronic metabolic diseases and intrauterine development is well documented in the academic literature, with several studies relating nutritional transition and the Developmental Origins of Health and Disease. The association between maternal malnutrition and short stature is evidenced by several studies and is associated with delayed intrauterine development, arterial hypertension, and cardiovascular diseases (CVD). Considering the high prevalence of CVDs and the association between oxidative stress and cardiac dysfunctions, this study aims to investigate the effects of alpha-tocopherol and tempol on cardiac autonomic modulation in rats submitted to intrauterine malnutrition and to evaluate the impact of treatment on the oxidative stress and regulation of Ca²⁺ transporting ATPases in the left ventricle. For this, rats were subjected to intrauterine growth retardation by inducing their mothers' dietary restriction during the gestational period. Some of the females were treated with alpha-tocopherol or tempol. In adulthood, it was observed that maternal dietary restriction induced an increase in baseline mean blood pressure in adult offspring and an increase in the values of very low-frequency and low-frequency oscillations in the spectral analysis of systolic blood pressure. In the spectral analysis of the pulse interval, the intrauterine malnourished animals showed an increase in the values of low-frequency oscillations and a decrease in high-frequency oscillations. The alterations coincided with an increase in oxidative stress and a change in the function of cardiac calcium-transporting ATPases. Treatments with α-tocopherol or tempol prevented changes in mean arterial pressure, variability in systolic arterial pressure, and pulse interval induced by intrauterine malnutrition, as well as preventing oxidative stress. The data indicate that treatments with alpha-tocopherol and tempol prevent activation of the sympathetic nervous system induced by intrauterine malnutrition, which may be one of the etiological mechanisms that favor the development of arterial hypertension in adult life.

COMMITTEE MEMBERS:
Presidente - 2069591 - LEUCIO DUARTE VIEIRA FILHO
Externa ao Programa - 3322031 - REGINA SOUZA AIRES - UFPEExterna ao Programa - 3245891 - NATALIA TABOSA MACHADO CALZERRA - UFPEExterno à Instituição - DIEGO BARBOSA DE QUEIROZ - UPE