Banca de QUALIFICAÇÃO: LUAN KELWYNY THAYWA MARQUES DA SILVA

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : LUAN KELWYNY THAYWA MARQUES DA SILVA
DATE: 30/06/2023
LOCAL: VÍDEO CONFERÊNCIA - GOOGLE MEET
TITLE:
KEY WORDS:
Phenotypic plasticity, neurodevelopmental disorders, colecalciferol.

PAGES: 65
BIG AREA: Ciências da Saúde
AREA: Nutrição
SUMMARY:
Phenotypic plasticity encompasses the ability of a particular individual to exhibit different characteristics in response to the environment in which it is immersed. This capacity is influenced by stimuli or insults that occur throughout life, altering gene expression without changes in the nucleotide sequence. However, the perinatal period represents a moment of great plasticity as the brain is more susceptible to external stimuli. Linked to nutrition, this period is also of great importance since early nutritional changes can have an impact throughout an individual's life. Additionally, one of the insults that can occur during critical periods of development is cerebral palsy (CP). CP is a complex syndrome that occurs in the developing brain. Its incidence leads to various problems such as motor, sensory, and cognitive deficits, as well as intestinal disorders, digestive problems, malnutrition, and nutritional deficiencies, such as vitamin D (VitD) deficiency. Although called a vitamin, vitamin D is actually a pro-hormone with wide participation in the body's homeostasis. In this context, the literature states that individuals affected by CP often have a deficit in VitD status. However, adequate levels of VitD must be maintained for both proper brain and musculoskeletal system development, as well as the maintenance of appropriate calcium and phosphorus concentrations to ensure a variety of metabolic functions. Moreover, VitD plays a significant role in the digestive system by promoting optimal levels of antimicrobial peptides and maintaining epithelial integrity. Based on this, the present study sought to evaluate the repercussions of neonatal administration of vitamin D on the intestine of rats subjected to an experimental model of cerebral palsy. For this purpose, the animals were divided into 4 experimental groups: Control+Vehicle, Control+Vitamin D, CP+Vehicle, and CP+Vitamin D. The animals in the CP groups underwent a protocol to induce CP through two episodes of perinatal anoxia associated with sensory-motor restriction of the lower limbs. VitD or vehicle was administered via intraperitoneal injection during the first 30 days of life. In the partial results regarding body weight, both control groups showed a gradual increase during the evaluated period; however, the Control+VitD group demonstrated a higher body weight in all assessments. In relation to the CP-induced groups, there was a significant difference in body weight until P28, where the CP+Vitamin D group had higher weights compared to CP+Vehicle. Regarding nasoanal length (NAL), from P14 onwards, an increase was observed in the Control+VitD group compared to Control+Vehicle, suggesting the effect of VitD on this parameter; whereas no statistical difference was found when comparing the CP+V and CP+Vitamin D groups. In the behavioral satiety sequence, it was observed that all experimental groups maintained the standard feeding structure. Furthermore, it was also noted that the behavioral satiety, defined as the transition point from feeding behavior to resting behavior, was advanced in the groups that received VitD administration.

COMMITTEE MEMBERS:
Externo ao Programa - 3296242 - DIEGO CABRAL LACERDA - nullExterno ao Programa - 1615555 - FRANCISCO CARLOS AMANAJAS DE AGUIAR JUNIOR - nullPresidente - ***.732.124-** - JOSE LUIZ DE BRITO ALVES - UFPE
Notícia cadastrada em: 20/06/2023 11:09
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