Banca de DEFESA: MARIA EDUARDA COLAÇO MESQUITA DA SILVA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : MARIA EDUARDA COLAÇO MESQUITA DA SILVA
DATE: 29/05/2024
TIME: 11:30
LOCAL: Programa de Pós-Graduação em Ciência de Materiais
TITLE:

SURFACE FUNCTIONALIZATION OF TITANIUM METAL WITH GRAPHENE OXIDE FOR BIOCOMPATIBLE COATINGS

KEY WORDS:

graphene oxide, medical devices, biofilm formation.

PAGES: 50
BIG AREA: Outra
AREA: Multidisciplinar
SUMMARY:

Biofilm formation is recognized as a significant cause of resistant infections, driving the development of innovative approaches in healthcare, such as nanomedicine, which employs nanomaterials and nanoparticles to combat bacteria. Antimicrobial nanostructures, such as graphene, offer advantages including low toxicity, the ability to overcome bacterial resistance, and reduced costs. This study aimed to develop and evaluate the biological properties of graphene oxide (GO) applied as a coating on titanium plates previously subjected to chemical etching. The coatings were composed of polymethyl methacrylate (PMMA) and graphene oxide (GO), with different GO exfoliation parameters and integration strategies with PMMA tested. The GO150w was synthesized from natural graphite using the modified Hummers-Offeman method, involving controlled addition of graphite and potassium permanganate in concentrated sulfuric acid, followed by water and hydrogen peroxide. Variations in synthesis and sonication parameters allowed obtaining graphene oxides with distinct properties. GO samples were tested for their ability to inhibit bacterial biofilms at different concentrations. The GO150w sample showed a 56.7% inhibition of Escherichia coli biofilm at higher concentrations, but solubility issues were observed after 24 hours. The GO7Kw sample had unsatisfactory results, with higher bacterial growth at the lowest concentration and only 30% inhibition at higher concentrations. On the other hand, the GONaNO3 sample achieved higher inhibition of biofilm formation against S. aureus bacteria, with 53.1% at the concentration of 1.0 mg/mL and approximately 49% at the concentration of 0.5 mg/mL. In the inhibition of biofilms formed by E. coli bacteria, a 43.4% inhibition was observed at the concentration of 1.0 mg/mL and 44.9% at 0.5 mg/mL, showing promise as an antimicrobial agent for biomedical applications.

COMMITTEE MEMBERS:
Interna - 2199290 - BEATE SAEGESSER SANTOS
Externa à Instituição - CELIA MACHADO RONCONI - UFF
Presidente - ***.487.700-** - GIOVANNA MACHADO - UFRGS