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Banca de QUALIFICAÇÃO: MARIA CLARA MULLER DE ANDRADE

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
DISCENTE: MARIA CLARA MULLER DE ANDRADE
DATA : 12/12/2024
LOCAL: Defesa remota
TÍTULO: Investigação dos mecanismos de ação antibacteriana de nanopartículas de prata.

PALAVRAS-CHAVES:

prata; nanopartículas; mecanismos; antibacteriana.

PÁGINAS: 34
RESUMO:

The antimicrobial activity of silver nanoparticles (AgNPs) has been extensively studied

over the last two decades. The literature contains a vast amount of data, primarily focused on

bacteria, and there are more than 1,000 registered AgNP-based products, including those used

in medical, textile, and cosmetic applications [1] Reviews by Yin et al. (2020) and Noronha et

al. (2017) highlight the potential applications of AgNPs in oral care, such as their incorporation

into acrylic resins for removable dentures, restorative materials, endodontic irrigants, implants,

adhesives, and caries arrestment formulations. [2], [3]. Even though cytotoxicity is a sensitive

concern regarding AgNPs, a recent systematic review concluded that silver used in dentistry

“at low concentrations is free of significant cytotoxicity” [4].

Our group was the first to demonstrate that AgNP-based formulations effectively arrest dental

caries. Clinical trials revealed that 67% of caries were arrested one year after a single

application of AgNPs [5]. Furthermore, in vitro assays confirmed the bactericidal and

bacteriostatic effects of AgNPs synthesized by our group against Streptococcus mutans—the

primary species responsible for caries—as well as other pathogenic bacteria [6], [7], [8], [9],

[10].

Despite substantial research, the precise antibacterial mechanisms of AgNPs remain

partially understood. Historically, these effects were attributed solely to the activity of Ag+ ions,

with AgNPs viewed merely as Ag+ precursors, distinguished from silver salts by their different

dissolution dynamics. It is well stablished that Ag+ act through multiple bactericidal pathways

including (i) disrupting cell wall and cytoplasmic membrane, (ii) denaturing ribosomes, (iii)

interrupting adenosine triphosphate (ATP) production, (iv) disrupting membrane by generating

reactive oxygen species (ROS); and (v) interfering on DNA replication. However, studies have

shown that AgNPs and silver salts releasing comparable amounts of Ag+ into the medium

induce differing levels of antimicrobial activity, raising questions about whether AgNP activity

is entirely attributable to extracellular Ag+ release [11]

MEMBROS DA BANCA:
Presidente - 1301657 - ANDRE GALEMBECK
Externo à Instituição - CHILDERICK SEVERAC
Interno - 1354207 - SEVERINO ALVES JUNIOR
Externa ao Programa - 2345892 - THAYZA CHRISTINA MONTENEGRO STAMFORD - null

Notícia cadastrada em: 10/12/2024 16:11