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LAYS RODRIGUES DA SILVA
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Advisor : ARMELE DE FATIMA DORNELAS DE ANDRADE
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COMMITTEE MEMBERS :
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DANIELLA CUNHA BRANDAO
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MAIRA FLORENTINO PESSOA
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RENATA JANAINA PEREIRA DE SOUZA
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Data: Feb 25, 2022
Ata de defesa assinada:
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ANA EUGÊNIA VASCONCELOS DO RÊGO BARROS
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Efficacy of telerehabilitation compared to face-to-face cardiopulmonary rehabilitation in COVID-19 survivors in relation to lung function, submaximal functional capacity and quality of life.
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Advisor : DANIELLA CUNHA BRANDAO
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COMMITTEE MEMBERS :
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SHIRLEY LIMA CAMPOS
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HELGA CECILIA MUNIZ DE SOUZA
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JÉSSICA COSTA LEITE
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Data: Mar 10, 2022
Ata de defesa assinada:
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Show Abstract
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This dissertation is structured in the form of an article that aimed to verify if there is superiority between telerehabilitation (TR) and face-to-face rehabilitation (PR) about pulmonary function, respiratory muscle strength, submaximal functional capacity and quality of life in COVID-19 survivor patients. This is an experimental study with a probability sample. To be included in the study, individuals needed to have a confirmed diagnosis of COVID-19 by RT-PCR. Patients who had not been hospitalized were allocated to the RT group, while those hospitalized were allocated to the RP. They were then submitted to the following assessments: spirometry, manovacuometry, six-minute walk test (6MWT) and answered the Medical Outcomes Study Short – Form 36 quality of life questionnaire. PR at the Cardiopulmonary Rehabilitation Center at Hospital das Clínicas de Pernambuco. The protocol consisted of four steps, namely: stretching, aerobic, strengthening and breathing exercises. In total, 12 sessions were held, twice a week. A total of 24 patients completed the protocol, 12 individuals in each group. There was an improvement in lung function and respiratory muscle strength in both groups, with no differences between them. Regarding submaximal functional capacity, there was an improvement in the RP group. In terms of quality of life, both groups obtained gains in all domains, except for social and emotional aspects in the PR group. There were no intergroup differences. Therefore, according to the findings of this study, there is no superiority between TR and PR in terms of pulmonary function, respiratory muscle strength and quality of life. About submaximal functional capacity, PR was superior.
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RÚBIA RAYANNE SOUTO BRAZ
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EFICÁCIA DO TREINO DE MULTICOMPONENTES ASSOCIADO ÀVIBRAÇÃO DE CORPO INTEIRO NO RISCO DE QUEDA E QUALIDADE DE VIDA EM IDOSOS OSTEOPORÓTICOS
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Advisor : MARIA DAS GRACAS RODRIGUES DE ARAUJO
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COMMITTEE MEMBERS :
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MARIA DAS GRACAS RODRIGUES DE ARAUJO
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MARCELO RENATO GUERINO
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MARIA DE FÁTIMA ALCÂNTARA BARROS
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Data: Mar 15, 2022
Ata de defesa assinada:
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Show Abstract
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CÉLIA KATIUSCIA DUARTE DANTAS MOURA
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Effectiveness and safety of resistance training after breast cancer surgery: an overview of systematic reviews
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Advisor : CAROLINE WANDERLEY SOUTO FERREIRA
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COMMITTEE MEMBERS :
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JULIANA NETTO MAIA
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MARIA DO AMPARO ANDRADE
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HELGA CECILIA MUNIZ DE SOUZA
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Data: Apr 25, 2022
Ata de defesa assinada:
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Resistance exercise training promotes a number of benefits in people's physical and mental health, however, it has historically been contraindicated in women with breast cancer-related lymphedema (LRCM) or at risk of developing it. Lymphedema is considered one of the main fears by these women because it is incurable and due to its progressive nature. The objective of this study was to evaluate the efficacy and safety of resistance training in women at risk of LRCM or with diagnosed lymphedema, through the analysis of systematic reviews. A bibliographic search was carried out in the main databases, followed by an assessment of the risk of bias of systematic reviews (SR) through the ROBIS tool, as well as the methodological quality through AMSTAR 2. Of the 5 RS found, 3 had a high risk of bias and 2 low risks. Regarding methodological quality, a critically low global confidence was found in all systematic reviews analyzed. There were no adverse effects related to the practice of resistance training by women with LRCM or at risk, and it can be performed safely, and showing benefits in quality of life and muscle strength.
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CAMILLA MEDEIROS ARAUJO
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Pad test for urinary incontinence diagnosis in adults: Systematic review of diagnostic test accuracy
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Advisor : DIEGO DE SOUSA DANTAS
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COMMITTEE MEMBERS :
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CAROLINE WANDERLEY SOUTO FERREIRA
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CINARA SACOMORI
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VANESSA PATRÍCIA SOARES DE SOUSA
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Data: Apr 27, 2022
Ata de defesa assinada:
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The pad test is a diagnostic tool for urinary incontinence (UI) severity classification and therapeutic response monitoring. However, the reliability and reproducibility of this test have been questioned. The objective was to investigate the quality of evidence from pad test accuracy studies on urinary incontinence diagnosis in adults compared to the urodynamic exam and summarize the accuracy and reproducibility properties. A systematic review of the diagnostic test accuracy was performed (PROSPERO: CRD42020219392). The eligibility criteria was studies that evaluated the diagnostic accuracy and reproducibility properties of four pad test protocols in adults of both sexes. Data sources was MEDLINE, Science Direct, Cochrane Database, Web of Science, LILACS, and Pedro databases. Two reviewers independently screened the eligibility of the articles. The risk of bias was evaluated with the QUADAS-2 tool. Eighteen studies, of which eight measured pad test accuracy, were included. A total of 1070 individuals were analyzed, the mean age ranged from 20 to 90 years. The risk of bias among the studies was high and, due to different cut-off points adopted by studies, the bivariate model was not satisfied to perform a meta-analysis. The accuracy of the long-duration protocols was generally moderate to high (sensitivity: 60%–93%; specificity: 60%–84%). The 1-hour protocols obtained higher accuracy values than the long-duration protocols. The overall reproducibility was moderate to high (κ ≥ 0.66). The 1-hour pad test had better accuracy, but poorer reproducibility compared to the long-duration tests. Pad test results should be used with caution in clinical practice.
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DÉBORA SIDRÔNIO CAETANO
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REGIONAL DISTRIBUTION OF PULMONARY VENTILATION IN CRITICAL PATIENTS WITH COVID-19
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Advisor : DANIELLA CUNHA BRANDAO
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COMMITTEE MEMBERS :
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ANTÔNIO CHRISTIAN EVANGELISTA GONÇALVES
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ARMELE DE FATIMA DORNELAS DE ANDRADE
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MARIA INES REMIGIO DE AGUIAR
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Data: May 16, 2022
Ata de defesa assinada:
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Although critically ill patients with COVID-19 meet the broader definition of ARDS, there is still conflicting evidence regarding the distribution of areas of pulmonary impairment and how these may influence oxygenation and ventilatory mechanics. In this scenario, the use of technologies for bedside diagnostic imaging such as Electrical Impedance Tomography (EIT) can help in clinical evaluation and decision making. Thus, the objective of this dissertation was to map the pulmonary hypoventilation regions of mechanically ventilated patients with ARDS secondary to COVID-19; and verify their association with respiratory system compliance and gas exchange. This is a secondary analysis of a clinical trial. A total of 53 participants hospitalized in an Intensive Care Unit specialized in the care of patients with COVID-19 on mechanical ventilation were selected. Pulmonary ventilation distribution was evaluated using Electrical Impedance Tomography (EIT), arterial blood gas analysis, and ventilatory mechanics. For analysis, the lung images were divided into quadrants of equal size, and the images were categorized according to the percentage of impedance variation (ΔZ) found in each quadrant. Four categories of distribution of areas of pulmonary hypoventilation were identified, in order of prevalence: preserved dorsal ventilation; unilaterally reduced dorsal ventilation; reduced dorsal ventilation bilaterally; preserved unilateral ventilation. Among the categories, patients with bilaterally reduced dorsal ventilation have a higher level of compromised oxygenation indicated by the PaO2/FiO2 ratio, however, there is no difference in respiratory system compliance values between the analyzed categories.
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10
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MILENE DE OLIVEIRA ALMEIDA
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COMPARISON BETWEEN KINESIOTHERAPY AND USUAL CARE DURING THE FIRST PERIOD OF LABOR IN MISOPROSTOL-INDUCED PREGNANT WOMEN: A RANDOMIZED CLINICAL TRIAL
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Advisor : ANDREA LEMOS BEZERRA DE OLIVEIRA
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COMMITTEE MEMBERS :
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ANDREA LEMOS BEZERRA DE OLIVEIRA
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LEILA KATZ
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CRISTINA KATYA TORRES TEIXEIRA MENDES
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Data: May 27, 2022
Ata de defesa assinada:
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INTRODUCTION: Misoprostol induction is one of the most used forms in clinical practice in maternity hospitals when the objective is to promote labor. However, induction does not always progress to vaginal delivery. Physiotherapeutic monitoring through kinesiotherapy is a strategy that can be used in this period and has several benefits, nevertheless, the study of the application of kinesiotherapy in induced women is not yet known. OBJECTIVE: To analyze the effectiveness of kinesiotherapy in the labor of pregnant women induced by misoprostol regarding the performance of vaginal deliveries when compared to the usual care group. METHODS: This is a clinical trial carried out at the Maternity Hospital of the Lauro Wanderley University Hospital of the Federal University of Paraíba HULW from January to December 2021 with pregnant women pharmacologically induced by misoprostol (25mcg, vaginally). The pregnant women were randomized into two groups: Intervention Group (IG): induced pregnant women who underwent kinesiotherapy during the active phase of labor; Control Group (CG): induced pregnant women who did not physical therapy during the active phase of labor. The variables studied were: vaginal delivery, induction time, duration of the active phase of labor, duration of the expulsive period of labor, number of misoprostol doses, pain level, grade 3 or 4 lacerations, and 5th-minute Apgar. Data were collected through pre-established collection forms and later analyzed by the Statistical Package for the Social Sciences (SPSS) program to perform statistical tests. RESULTS: The sample of pregnant women in the intervention group had a greater number of vaginal deliveries (p=0.016). The variables induction time, duration of the active phase and expulsive period, pain level, presence of laceration, Apgar, and fetal weight had no difference between groups. CONCLUSION: Kinesiotherapy during the active phase of labor in women induced by misoprostol was effective for performing more vaginal deliveries despite not showing any difference in the other outcomes studied.
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SÔNIA ELVIRA DOS SANTOS MARINHO
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EFFECTS OF USING ADAPTED DIVING MASK (OWNER) AND CONVENTIONAL OROFACIAL MASK IN PATIENTS WITH AND WITHOUT COVID-19 DIAGNOSIS WITH NIV INDICATION ON OXYGENATION AND NON-INTUBATION: RANDOMIZED CLINICAL TRIAL
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Advisor : PATRICIA ERIKA DE MELO MARINHO
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COMMITTEE MEMBERS :
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ANNA MYRNA JAGUARIBE DE LIMA
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MARIA DA GLORIA RODRIGUES MACHADO
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SELMA SOUSA BRUNO
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Data: Jul 12, 2022
Ata de defesa assinada:
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Covid-19 causes several systemic manifestations, especially affecting the respiratory system, ranging from mild cold symptoms to severe acute respiratory distress syndrome (ARDS). At the beginning of the pandemic, there was a recommendation for early intubation in order to avoid respiratory deterioration and further lung injury, and non-invasive ventilation (NIV) was seen as an unsafe method for such patients due to the lack of scientific evidence for this and previous research involving viral pneumonias. The objective of this research was to compare the effects of the use of the adapted diving mask (Owner) with the conventional orofacial mask in patients with and without the diagnosis of Covid-19 with NIV indication regarding oxygenation and non-intubation. This is a randomized clinical trial, resulting from a larger study, approved by the Research Ethics Committee and the National Research Ethics Committee (CAAE: 30783720.7.0000.5343, opinion nº. 4.305.813), respecting all the norms of the Resolution 466/12 of the National Health Council and registered in the Brazilian Clinical Trial Registry (ReBEC) (RBR – 7xmbgsz). Patients admitted to the intensive care units (ICU) of two hospitals, of both sexes, aged between 18 and 90 years and with an indication for NIV due to ARDS, were included in the study. 48 patients were recruited. Patients diagnosed with Covid-19 were considered to be those with a positive reverse transcriptase test (RT-PCR) or serological test. The primary outcomes studied were the PaO2/FiO2 ratio (RPaO2/FiO2) as a parameter to assess oxygenation and NIV success (non-evolution to intubation/death). The normality and homogeneity of the sample were verified, respectively, through the Kolmorogov-Smirnov and Levene tests. Single-factor ANOVA was used to evaluate the behavior of RPaO2/FiO2 (before NIV, after 1h, 24h and 48h). The Mauchly sphericity test and the Greenhouse-Geisser correction were performed. For the post hoc analysis, the Sidak test was used (P<0.05). Statistical analysis was performed using SPSS version 20.0. Patients with Covid-19 were allocated in the adapted diving mask group (G1, n=12) and in the conventional orofacial mask group (G2, n=12) and the patients without Covid-19 were allocated in the adapted diving mask group (G3, n=12) and conventional orofacial mask group (G4, n=12). There was no sample loss. The adapted and conventional diving masks differed from each other regarding the behavior of RPaO2/FiO2 in 1h (309.66±11.48 vs. 275.708±11.48, respectively) (p= 0.042) and in 48h (365.81± 16.85 vs. 308.787±18.86, respectively) (p=0.021). The success of NIV (non-intubation) was high in all groups, with 91.7% in G1, G3 and G4 and 83.3% in G2, demonstrating a low failure rate in all groups. It is concluded that NIV was safe and effective in the evaluated patients and there was a better result of the adapted diving mask in improving RPaO2/FiO2 and in terms of non-intubation.
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CLÁUDIA REGINA DA SILVA ARAÚJO
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Endothelial function, arterial stiffness, heart rate variability, and clinical outcomes of adults with cardiovascular diseases hospitalized due to COVID-19
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Advisor : DANIELLA CUNHA BRANDAO
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COMMITTEE MEMBERS :
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MARIA DA GLORIA RODRIGUES MACHADO
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MARIA INES REMIGIO DE AGUIAR
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SHIRLEY LIMA CAMPOS
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Data: Jul 13, 2022
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Introduction: COVID-19 is a systemic disease characterized by pro-inflammatory, pro-oxidative, prothrombotic state, excess circulating cytokines, dysregulation of the nine-year-old system, autonomic dysfunction and tissue lesions, which may cause changes in endothelial function, vascular structure and exacerbation of previous cardiovascular diseases. Thus, patients with underlying cardiovascular risk factors are prone to greater severity of the disease and worse prognosis. Objective: To evaluate the endothelial function, arterial stiffness and heart rate variability (HRV) of adults with CVD hospitalized by COVID-19 and to relate them to clinical outcomes. Methods: Cross-sectional study conducted from July 2020 to February 2021 at Hospital Agamenon Magalhães, Pernambuco, Brazil. A convenience sample of adults of both sexes, aged 40 to 60 years, hospitalized with COVID-19 and previous CVD was selected. Personal data, comorbidities, admission laboratory tests, in addition to clinical outcomes and possible clinical complications during hospitalization were analyzed. Endothelial function, arterial stiffness and HRV were evaluated by peripheral arterial tonometry. The sample was categorized according to endothelial dysfunction and statistical significance was set at 5%. Resultados: Fourteen of the twenty (51.8%) and seven adults included had endothelial dysfunction (median natural logarithm of the reactive hyperemia index of 0.29, interquartile interval between 0.06 and 0.42). The rate of increase normalized for heart rate (75 beats per minute) was significantly high in patients with preserved endothelial function (p<0.01), suggesting a high rate of arterial stiffness. Patients with endothelial dysfunction had higher values of high frequency (p<0.03) of HRV. No differences were observed between the groups in relation to clinical outcomes. Conclusion: This study shows that the endothelial function assessed by PAT seems to be an important early marker of endothelial dysfunction, arterial stiffness and VhF in patients with CVD hospitalized by COVID-19.
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MAYARA CRISTINA MACÊDO DE MENEZES
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ANALYSIS OF MEASUREMENT PROPERTIES OF INSTRUMENTS FOR THE IMPACT OF MIGRAINE IN BRAZIL: A SYSTEMATIC REVIEW
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Advisor : DANIELLA ARAUJO DE OLIVEIRA
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COMMITTEE MEMBERS :
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ANGELICA DA SILVA TENORIO
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JULIANA FERNANDES DE SOUZA BARBOSA
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MANUELLA MORAES MONTEIRO BARBOSA BARROS
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Data: Aug 25, 2022
Ata de defesa assinada:
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Show Abstract
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Introduction: The evaluation of the measurement properties of patient-reported outcome measures (PROMs) is necessary for professionals and researchers to select instruments that guarantee the quality of the results. Thus, reliable instruments are important to provide information on the impact of migraine. Objective: To analyze the properties of measures of instruments that assess the impact of migraine developed for the Brazilian population. Methods: A search was performed in February 2021 and an update in June 2021 in the MEDLINE/Pubmed, Web of Science, LILACS and Embase databases, including studies that evaluated properties of PROMs measures developed to assess the impact caused by migraine, and translated and validated for the Brazilian population. Methodological quality, risk of bias, and quality of evidence were assessed following the COnsensus-based Standards for the selection of health Measurement INstruments (Cosmin) guidelines for systematic reviews of PROMs. Results: A total of 112 studies were identified, and four were included for full reading. Three instruments were analyzed: Headache Impact Test, which presented a serious risk of bias with moderate quality of evidence; Pediatric Migraine Disability Assessment, which had an extremely severe risk of bias and very low quality of evidence; and the Headache Disability Inventory¸ which presented a very serious risk of bias and low quality of evidence. Conclusion: The analysis performed identified that the three instruments evaluated had important limitations in the quality of evidence of the instruments evaluated. The Headache Impact Test was the most recommended for presenting moderate quality of evidence.
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ANDRÉA KARLA SOARES MONTENEGRO
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EFFECTS OF PHYSICAL EXERCISE ON THE FUNCTIONAL CAPACITY AND MUSCLE STRENGTH OF PATIENTS WITH GASTRIC AND ESOPHAGEAL CANCER: A SYSTEMATIC REVIEW
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Advisor : DIEGO DE SOUSA DANTAS
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COMMITTEE MEMBERS :
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DIEGO DE SOUSA DANTAS
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DANIELLA CUNHA BRANDAO
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DIEGO NEVES ARAUJO
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Data: Aug 29, 2022
Ata de defesa assinada:
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Show Abstract
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The clinical management of esophageal or gastric cancer involves a combination of treatments, neoadjuvants and surgical resection. The malnutrition inherent to this type of cancer results in a decline in functional capacity (FC) and muscle strength (FM). The objective of this review is to evaluate the evidence on the effects of physical exercise on the functional capacity of patients with esophageal and stomach cancer. This is a systematic review of randomized clinical trials that evaluated the impact of an exercise program on the functional capacity of patients with esophagogastric cancer. The searches involved PubMed, PEDro, Cochrane Library, Embase and CINAHL databases. The primary outcome of the review was FC. FM appeared as a secondary outcome. The risk of bias was assessed using the Cochrane Collaboration tool, using the RevMan software, and the degree of evidence was assessed using the GRADE system. Of 111 articles screened, eight studies involving a total of 673 patients were included in the qualitative synthesis. The studies varied in terms of measures of functional capacity, exercise protocols, and the therapeutic time at which the training program was implemented (during neoadjuvant therapy, pre- or post-surgical). The approach during neoadjuvant therapy had a positive effect on the 6-minute walk test (6MWT) and on handgrip strength (HPF), p<.05. The effect of the exercise performed in the preoperative period presented divergent results for the inspiratory muscle strength (PImax), being inconclusive for this outcome. However, in the assessment of functional capacity by the 6MWT, the result was statistically significant (p<0.001). The implementation of exercise in the postoperative period had an impact on the improvement of the 6MWT, maximum oxygen consumption (VO2max). However, in the assessment of muscle strength by HGS, there was no significant difference between the groups (p=0.758). Although some studies point to positive results in favor of physical exercise in improving functional capacity and muscle strength in patients undergoing treatment for esophagogastric cancer, further research is needed, not only to confirm the existing evidence but also for a better prescription and clinical application of these intervention protocols.
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MIKAELA APARECIDA DE OLIVEIRA XAVIER
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Efficacy of Pelvic Floor Muscle Training on the Sexual Function of Men after Radical Prostatectomy: An Overview of Systematic Reviews
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Advisor : DIEGO DE SOUSA DANTAS
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COMMITTEE MEMBERS :
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DIEGO DE SOUSA DANTAS
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CINARA SACOMORI
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VANESSA PATRÍCIA SOARES DE SOUSA
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Data: Aug 29, 2022
Ata de defesa assinada:
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Show Abstract
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This study aimed to evaluate the evidence in the literature on the efficacy of pelvic floor muscle training on the sexual function (SF) of men after prostatectomy by an overview of systematic reviews (SR) of randomized clinical trials. The search for studies was conducted in five databases without any language restriction: EMBASE, PUBMED, Science Direct, PEDro, and Cochrane Library. The main results were extracted from the SR by two reviewers, and meta-analysis was performed from the primary studies for the outcomes SF scores and erectile dysfunction. 4 reviews were included in the qualitative synthesis, which involved 8 clinical trials and 891 participants. The reviews had moderate to good methodological quality, but a high overlap of clinical studies was founded. Meta-analysis showed that pelvic floor muscle training improves sexual function scores not in 3 months (p=0.51) but in 6 months (p=0.02) and it did not show efficacy on erectile dysfunction after three (p=0.58) and 12 months (p=0.32). Studies with moderate to good methodological quality demonstrate that pelvic floor muscle training only improve sexual function score in 6 months, but not had efficacy in erectile dysfunction in men after prostatectomy.
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DANIELLY LIMA DE ANDRADE
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Acute effect of neuromuscular electrostimulation and kinesiotherapy on ankle joint flexibility, infrared radiation and strength of the triceps suralis of women with chronic venous insufficiency: a comparative study.
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Advisor : MARIA DO AMPARO ANDRADE
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COMMITTEE MEMBERS :
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ANA PAULA DE LIMA FERREIRA
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ANGELICA DA SILVA TENORIO
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MARIA DO SOCORRO BRASILEIRO SANTOS
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Data: Aug 30, 2022
Ata de defesa assinada:
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Show Abstract
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Introduction: chronic venous insufficiency (CVI) is a change in the venous system due to a valve inability, generating reflux that is associated or not with venous flow obstruction, and might be caused by dysfunction in the muscles of the sural triceps. The purpose of this study was to evaluate the acute effect of neuromuscular electrostimulation and kinesiotherapy on ankle joint flexibility, infrared radiation and sural triceps strength of individuals with CVI.
Method: this is a comparative study. Which infrared radiation was obtained by quantitative analysis of thermograms of both calves using thermographic camera; to evaluate ankle flexibility, the ‘‘goniometer’’ application was used and a portable dynamometer was used to evaluate the muscle strength of dorsiflexion and plantar flexion. One session of electrostimulation was performed by the Aussie current of 1kHz with Burst of duration equal to 2 ms (EG- electrostimulation group), in the right lower limb and kinesiotherapy (GC-kinesiotherapy group) in the left lower limb with stretching and metabolic exercises involving the ankle.
Results: 19 female patients were evaluated. Ankle flexibility analysis did not show statistically significant changes. In the evaluation of muscle strength there was no intergroup difference and in the intragroup evaluation only the CG showed an increase for dorsiflexion when compared to before treatment and 24 h after (respectively 11.6±3.5; 13.5±3.0, p=0.02), and for plantar flexion (11.8±6.3; 14.4±5.06, p=0.04). There was no statistically significant difference when intergroups and intragroup flexibility was evaluated. Regarding thermography, there was no intragroup difference while in the intergroup evaluation, the CG presented an increase in temperature immediately and 24 hours after (respectively 0.44±0.68, p=0.01 and 0.25±0.83, p=0.07). When analyzed the correlation between dorsiflexion force and plantar flexion of both lower body with the amplitude of the total arch of the right and left ankle, a positive correlation was observed only between plantar flexion strength immediately after and 24 hours after ankle ROM (rang of movement) in the kinesiotherapy group (respectively r=0.49, p=0.03 and r=0.51, p=0.03). Conclusion: There were no significant differences between the kinesiotherapy procedure and electrotherapy when analyzing muscle flexibility and strength. However Kinesiotherapy was superior to electrostimulation in the increase in calf temperature before and after 24 hours of the intervention.
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RENATA CRESPO SIMAS TOSCANO
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Cross-cultural adaptation to Brazilian Portuguese and analysis of the measurement properties of the Impact of Brachial Plexus Injury Questionnaire
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Advisor : DANIELLA ARAUJO DE OLIVEIRA
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COMMITTEE MEMBERS :
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ANDREA LEMOS BEZERRA DE OLIVEIRA
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SHIRLEY LIMA CAMPOS
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ETIENE OLIVEIRA DA SILVA FITTIPALDI
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Data: Aug 30, 2022
Ata de defesa assinada:
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Show Abstract
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Traumatic brachial plexus injury (LTPB) is a complex condition, with slow recovery and high cost due to expenses during treatment as well as due to the impact on individual labor productivity. In the literature, the Impact of Brachial Plexus Injury Questionnaire is available, which assesses the physical and psychological impacts in the pre- and/or post-surgical period, as well as the amount of expectation of improvement, but in Brazil there are no specific instruments for this population. Thus, the present study initially aimed to carry out the translation and adaptation into Brazilian Portuguese, following the international guidelines of the International Society for Pharmacoeconomics and Outcomes Research (ISPOR). A Delphi study was carried out to give greater reliability to the adaptation process. After consensus, the adapted instrument was applied to the target population. The sample consisted of patients with LTPB (in the pre- or post-surgical period), recruited from the peripheral nerves outpatient clinic of Hospital da Restauração and Hospital Getúlio Vargas, Recife/PE. The analysis of measurement properties was performed through content validity, convergent validity, criterion validity, internal consistency, and floor and ceiling effect, this step followed the recommendations of the Consensusbased Standards for the Selection of Health Measurement Instruments (COSMIN). It has a valid internal structure with four subscales, a disability domain and 43 items, with good content validity, showing good applicability and understanding by the target audience. The Brazilian Portuguese version of the IBPIQ had a good internal consistency of 0.85 in the disability domain and a range of 0.66 to 0.93 in the subscales; good convergent validity with significant and positive correlations with DASH in the limitation (r = 0.54) and emotion (r = 0.50) subscales and a moderate magnitude correlation with the disability domain (r = 0.44); criterion validity compared by surgery, showed significant differences between patients who underwent vs. did not undergo surgery in the limitation subscale scores [F(1, 48) = 4.23; p = 0.045], expectation of improvement [F(1, 48) = 4.72; p = 0.035], and total score [F(1, 48) = 4.41; p = 0.041] while In the comparisons of scores by type of injury, no comparison was significant. No floor and ceiling effect was observed. The IBPIQ-Br showed good content validity, internal consistency, convergent validity with moderate correlation with another instrument and criterion validity.
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ALANA CRISTINA CAMPOS E SILVA
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Association of handgrip strength with quality of life in breast cancer survivors: a systematic review and meta-analysis
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Advisor : DIEGO DE SOUSA DANTAS
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COMMITTEE MEMBERS :
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CAROLINE WANDERLEY SOUTO FERREIRA
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NAYARA PRISCILA DANTAS DE OLIVEIRA
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CINARA SACOMORI
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Data: Aug 31, 2022
Ata de defesa assinada:
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Show Abstract
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Handgrip strength is an indicator of general muscle strength and in cancer patients it acts as a relevant marker associated with mortality and health. The systematic review aimed to assess the association between peripheral muscle function and health-related quality of life in breast cancer survivors. A registered systematic review was performed (PROSPERO: CRD 42021225206). Searches were performed in MEDLINE via Pubmed, PEDro, Cochrane Library, Embase, CINAHL via EBSCO and Science Direct databases. Observational studies evaluating the association between handgrip strength and health-related quality of life in adult female breast cancer survivors were included. No language or time restrictions were applied. Two reviewers reviewed full texts for inclusion and performed data extraction and risk of bias using the Newcastle and Ottawa scale. Five articles were included and involved 587 patients, with a mean age of 47 to 59 years. The percentage of decreased handgrip strength ranged from 38.3% to 60.3%. Handgrip strength was associated with different measures of quality of life. From the meta-analysis including 220 patients, the correlation coefficient between handgrip strength and health-related quality of life was 0.26 (95% CI: 0.07-0.35). Thus, we conclude that breast cancer survivors face a decline in handgrip strength. In this population, handgrip strength was correlated with health-related quality of life. However, more evidence is needed.
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RÔMULO DE AQUINO COELHO LINS
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Respiratory and hemodynamic repercussions of different PEEP titration strategies in patients with moderate ARDS by Covid-19: an exploratory analysis.
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Advisor : SHIRLEY LIMA CAMPOS
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COMMITTEE MEMBERS :
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DANIELLA CUNHA BRANDAO
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ANTÔNIO CHRISTIAN EVANGELISTA GONÇALVES
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MARIA DA GLORIA RODRIGUES MACHADO
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Data: Aug 31, 2022
Ata de defesa assinada:
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Show Abstract
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Background:Severe cases of COVID-19 can develop severe acute respiratory syndrome (ARDS), characterized by severe hypoxemia and respiratory failure, requiring orotracheal intubation and mechanical ventilatory support. Positive end-expiratory pressure (PEEP), one of the parameters of the protective ventilatory strategy, must be individualized in order to optimize oxygenation, reduce lung injuries and deleterious outcomes. Among the different methods of PEEP titration for patients with respiratory failure, there is still no consensus on the ideal method of PEEP titration for patients with Covid-19.
Objective:To describe the acute response over four hours post-titration of PEEP by PEEP table vs. Driving pressure guided PEEP on oxygenation and gas exchange, respiratory mechanics and hemodynamics.
Methods:Exploratory analysis of the NTC U1111-1255-6129 study, in which oxygenation and gas exchange (ratio between PaO2/FiO2, peripheral oxygen saturation - Peripheral oxygen saturation - SpO2), respiratory mechanics (Peak pressure, Plateau pressure, driving pressure (DP), (Static compliance - Cest, Airway resistance - Rva) and hemodynamics (Heart rate - HR, Mean arterial pressure - MAP) of patients with moderate ARDS by Covid-19, submitted to titration by PEEP table and Driving Pressure guide-PEEP were monitored after 0.5, 1, 2 and 4 hours.
Results:In the sample stratum of 27 patients, for most baseline clinical characteristics at admission there were no differences between groups, except for PaO2/FiO2 (PEEP table, median 128.7 [IQ 117-175] vs. guided-PEEP DP, median 140.0 [ IQ 138-178}, p=0.005). In the linear model, corrected for baseline PaO2/FiO2, there were differences only for SpO2 in the group x moment interaction (p=0.004). PEEP 10 cmH2O was titrated in 93.3% of cases in the PEEP table group and in 91.7% of cases titrated by DP guided PEEP (p = 0.167).
Conclusions:The titrated PEEP in the Covid-19-moderate ARDS sample had a frequent value of 10 cmH2O in the PEEP table and DP guided PEEP groups, also generating similar clinical responses after 4 hours of titration for oxygenation, gas exchange and respiratory mechanics.
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22
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EDY KATTARINE DIAS DOS SANTOS
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IDENTIFICATION OF COMMON CONTENT OF THE INTERNATIONAL CLASSIFICATION OF FUNCTIONING, DISABILITY AND HEALTH (ICF) IN OUTCOME MEASURES REPORTED BY PATIENTS WITH TYPE 2 DIABETES
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Advisor : MARIA DAS GRACAS RODRIGUES DE ARAUJO
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COMMITTEE MEMBERS :
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ALINE BRAGA GALVÃO SILVEIRA FERNANDES
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DANIELLA ARAUJO DE OLIVEIRA
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JULIANA FERNANDES DE SOUZA BARBOSA
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Data: Aug 31, 2022
Ata de defesa assinada:
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Show Abstract
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Introduction: Type II diabetes mellitus is a metabolic disease with a high prevalence, responsible for clinics and high demand for self-management. The use of patient-reported health outcome measures (PROMs) assist healthcare professionals in evaluating treatment strategies. The International Classification of Functioning (ICF), in turn, operationalizes the biopsychosocial model for a broader understanding of the health condition of people with diabetes. Objective: Binding instruments validated PROMs for patients with Type II Diabetes and the ICF, in order to identify differences between the components and describe a common appearance of the ICF. Study method was developed in two steps: (i) identification of validated PROMs and specificity for type 2 diabetes, and (ii) linkage between the instruments and the ICF through the ICF linking methodology proposed by Cieza et al. Additionally, a list of proposed categories was used to classify personal factors. Such methodology, among other conclusions and proposals, the identification of issues and the correspondence with representative ICF categories to the other conclusions and proposals in the PROMs. Results: From the 12 PROMs included, 184 statements were identified that were linked to 84 different categories, 78 of which were from the ICF and from the list of personal factors. Of these, 40% body function, 38% activity and participation, 8% environmental factors, 7% body structure followed by 7% personal factors. The categories were cited 365 times, and the activity and participation component was the most representative component. The most cited categories are related to health control of food, self-care and management activities in physical contexts. Conclusion: Overall, PROMs included in the ICF coverage, covering all categories of structure and function of activity and participation, environmental and personal factors to describe the components of patients with type II diabetes. There is divergence as to the degree of coverage of these components among the PROMs.
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23
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IRIS FERNANDA IVONE DE MEDEIROS AMORIM
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PERIPHERAL MUSCLE STRENGTH AND FUNCTIONAL CAPACITY OF POST-COVID-19 INDIVIDUALS: A CROSS-SECTIONAL STUDY
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Advisor : MARIA DAS GRACAS RODRIGUES DE ARAUJO
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COMMITTEE MEMBERS :
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SHIRLEY LIMA CAMPOS
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CAIO CESAR ARAUJO MORAIS
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SILVANA LOANA DE OLIVEIRA SOUSA
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Data: Sep 6, 2022
Ata de defesa assinada:
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Show Abstract
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INTRODUCTION: Since December 2019, the world faces the SARS-CoV-2 pandemic, popularly known as the new coronavirus. Infection by the new coronavirus originating from Covid-19, which is characterized as a disease with high power of dissemination and mortality. The symptoms and complications of the disease will determine the type of therapeutic support that will be offered to infected individuals. Mild infection cases are advised to carry out home isolation, while more severe cases require hospitalization. After hospital discharge, survivors of Covid-19, especially those who required admission to the ICU, may present some sequelae resulting from the complications of viral infection. Understanding that the effects of coronavirus infection can affect several organ systems, in addition to respiratory function, such as the cardiovascular and musculoskeletal system, it becomes relevant to investigate the musculoskeletal and vascular functional status in the period after coronavirus infection. OBJECTIVE: To evaluate the peripheral muscle strength and vascular function of post-Covid-19 individuals who were hospitalized in the ward, ICU or in isolation at home after discharge and after 6 months. METHODOLOGY: This is an analytical, observational study, with a longitudinal and prospective temporality, since all participants will undergo an initial evaluation and a 6-month follow-up. Data collection will be divided into 4 stages, the first stage consists of conducting an interview with the participants to collect personal data and clinical history. Subsequently, the assessment of peripheral vascular function will be performed with peripheral vascular Doppler ultrasound, infrared thermography and ankle-brachial index. The third step consists of the evaluation of the musculoskeletal system to verify muscle strength with the MRC scale and digital manual dynamometer Microfet2, finally, the 6-minute walk test will be performed to assess functionality and tolerance to submaximal exercise. Statistical analysis will be performed using SPSS software (Statistical Package for Social Science) version 20.0 for Windows and the significance level adopted will be α<0.05 for all analyses. To analyze the association between categorical variables and intergroup and intragroup quantitative variables, analysis of variance (ANOVA) and analysis of variance for repeated measures (MANOVA) or the Friedman test will be performed, according to the type of sample distribution. Finally, the data obtained will be presented in tables and/or graphs.
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24
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CLÁUDIA REGINA DA SILVA ARAÚJO
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Endothelial function, arterial stiffness, heart rate variability, and clinical outcomes of adults with cardiovascular diseases hospitalized due to COVID-19
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Advisor : DANIELLA CUNHA BRANDAO
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COMMITTEE MEMBERS :
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MARIA DA GLORIA RODRIGUES MACHADO
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MARIA INES REMIGIO DE AGUIAR
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SHIRLEY LIMA CAMPOS
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Data: Oct 31, 2022
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Show Abstract
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Introduction: COVID-19 is a systemic disease characterized by pro-inflammatory, pro-oxidative, prothrombotic state, excess circulating cytokines, dysregulation of the nine-year-old system, autonomic dysfunction and tissue lesions, which may cause changes in endothelial function, vascular structure and exacerbation of previous cardiovascular diseases. Thus, patients with underlying cardiovascular risk factors are prone to greater severity of the disease and worse prognosis. Objective: To evaluate the endothelial function, arterial stiffness and heart rate variability (HRV) of adults with CVD hospitalized by COVID-19 and to relate them to clinical outcomes. Methods: Cross-sectional study conducted from July 2020 to February 2021 at Hospital Agamenon Magalhães, Pernambuco, Brazil. A convenience sample of adults of both sexes, aged 40 to 60 years, hospitalized with COVID-19 and previous CVD was selected. Personal data, comorbidities, admission laboratory tests, in addition to clinical outcomes and possible clinical complications during hospitalization were analyzed. Endothelial function, arterial stiffness and HRV were evaluated by peripheral arterial tonometry. The sample was categorized according to endothelial dysfunction and statistical significance was set at 5%. Resultados: Fourteen of the twenty (51.8%) and seven adults included had endothelial dysfunction (median natural logarithm of the reactive hyperemia index of 0.29, interquartile interval between 0.06 and 0.42). The rate of increase normalized for heart rate (75 beats per minute) was significantly high in patients with preserved endothelial function (p<0.01), suggesting a high rate of arterial stiffness. Patients with endothelial dysfunction had higher values of high frequency (p<0.03) of HRV. No differences were observed between the groups in relation to clinical outcomes. Conclusion: This study shows that the endothelial function assessed by PAT seems to be an important early marker of endothelial dysfunction, arterial stiffness and VhF in patients with CVD hospitalized by COVID-19.
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25
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VIVIANE WANDERLEY MASTROIANNI
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REPERCUSSÕES DA ASSISTÊNCIA VENTILATÓRIA MECÂNICA INVASIVA NA TOLERÂNCIA AO EXERCÍCIO MÁXIMO, FORÇA MUSCULAR RESPIRATÓRIA, FUNÇÃO PULMONAR E QUALIDADE DE VIDA EM ADULTOS SOBREVIVENTES À FORMA MODERADA E GRAVE DA COVID-19
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Advisor : DANIELLA CUNHA BRANDAO
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COMMITTEE MEMBERS :
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ANNA MYRNA JAGUARIBE DE LIMA
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SHIRLEY LIMA CAMPOS
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FABIANNE MAISA DE NOVAES ASSIS DANTAS
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Data: Nov 8, 2022
Ata de defesa assinada:
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Show Abstract
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A COVID-19 reponsável pela pandemia desde 2020 com facil disseminação do vírus SAR-CoV-2 pode trazer manifestações físicas, dentre elas sintomas musculoesqueléticos que podem persistir após o témino da fase inicial da doença conhecida como sídrome pós COVID-19, caracterizando assim a necessidade de cuidados de reabilitação. Diante disso, a vibração de corpo inteiro (tratamento físico realizado através da potenciação neurogênica a partir de vibrações mecânicas) pode ser eficaz como tratamento por proporcionar repercussões musculares e de condicionamento cardovascular já conhecidas em pacientes renais, transplantados, idosos, e outras doenças. Este estudo tem o objetivo de avaliar os efeitos de um programa de treinamento com VCI sobre a capacidade funcional, a força muscular do quadríceps femoral e a preensão palmar, a espessura do músculo quadríceps, a funcionalidade e a qualidade de vida de pacientes recuperados da forma moderada ou grave da COVID-19. Trata-se de um ensaio clínico randomizado, controlado e cego, constituído por 3 grupos de pacientes que receberão a intervenção sobre a plataforma vibratória (amplitude de 4mm, 2mm e o grupo sham), e cada paciente receberá 36 sessões, 3 vezes por semana com avaliação prévia e reavaliação posterior. Os desfechos primários serão a capacidade funcional e a força muscular periférica e os desfechos secundários serão Força muscular respiratória, espessura do músculo quadríceps, funcionalidade e qualidade de vida.
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26
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TATYANE GOMES DE OLIVEIRA
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POST-TRAUMATIC STRESS DISORDER, BODY COMPOSITION, MUSCLE STRENGTH AND THICKNESS, FUNCTIONAL CAPACITY AND QUALITY OF LIFE OF POST COVID-19 PATIENTS: A CROSS-SECTIONAL STUDY
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Advisor : PATRICIA ERIKA DE MELO MARINHO
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COMMITTEE MEMBERS :
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MARIA DAS GRACAS RODRIGUES DE ARAUJO
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JULIANA FERNANDES DE SOUZA BARBOSA
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CRISTIANO DOS SANTOS GOMES
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Data: Nov 30, 2022
Ata de defesa assinada:
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Show Abstract
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The main systemic manifestations of patients with COVID-19, highlights the commitment of cardiovascular, metabolic and central nervous systems, as well as musculoskeletal dysfunctions and emotional impacts due to traumatic events during hospitalization. Post traumatic stress disorder (PTSD), characterized by involuntary and intrusive distressing memories can be considered an emotional impact that deserves to be investigated. The objective of this research was to verify the prevalence of PTSD and its association with body composition, muscle strength and thickness, functional capacity and quality of life of patients who had the moderate and severe form of COVID-19, after a minimum period of four months after discharge from the ward and/or ICU. This is a cross-sectional study, approved by the institutional ethics committee (CAAE: 43309621.6.0000.5208), under the number of opinion nº 4,666,479 and developed at the Cardiopulmonary Physiotherapy Laboratory of the Department of Physiotherapy of the Federal University of Pernambuco. Individuals of both sexes, aged between 45 and 70 years, who had COVID-19 duly proven and who had been admitted to the ICU or ward and presented clinically recovered, from the 4th month of recovery, were included. Individuals with musculoskeletal changes that prevented the performance of functional tests, cognitive changes that hindered the understanding of the questionnaires, hemodynamic instability and who performed a post-discharge training program were excluded from the study. Individuals were evaluated for PTSD, level of physical activity quality of life, body composition, inspiratory and expiratory muscle strength, palmar grip strength, mobility and balance, quadriceps muscle thickness of the dominant lower limb, distance covered in the 6 min walk test and quality of life. This dissertation presents as results the following articles: "Risk factors associated with post-traumatic stress disorder in post-COVID-19 patients: a systematic review". In this review, it was observed that factors such as the female gender, age group between 40 and 50 years and previous pathologies mainly of psychological order constituted risk factors associated with PTSD in post-COVID-19 patients. It was also observed that education level, economic status, belief in increased mortality from COVID-19, admission to the ICU, length of hospital stay, The death of a patient in the ICU and isolation during hospitalization also contributed to higher rates of PTSD. And an original article: "Post-traumatic stress Disorder in individuals who required Hospitalization for COVID-19: A cross-sectional Study". The prevalence of PTSD in the individuals evaluated was 48.3%, however, another 38.7% had partial symptoms. In individuals with PTSD, 65.5% were obese, 62.1% hypertensive and sedentary (p = 0.009). These individuals had hospitalization in the ICU and a higher number of days hospitalized, respectively (p <0.001 and p = 0.010). As for functionality, individuals with PTSD also had more time to perform the TUG (p = 0.014), less distance covered predicted in 6MWT min (p = 0.001) and reduction in all domains of the SF-36 questionnaire. As a conclusion, there is a relative prevalence of PTSD after 4 months of hospital discharge in individuals recovered from COVID-19 and functional repercussions.
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NATALIA TARCILA SANTOS AMORIM
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EFFECTIVENESS OF A WHOLE-BODY VIBRATION PROTOCOL ON THE RISK OF FALLS, BALANCE AND HEART RATE VARIABILITY OF PATIENTS POST-COVID-19: RANDOMIZED CONTROLLED STUDY
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Advisor : PATRICIA ERIKA DE MELO MARINHO
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COMMITTEE MEMBERS :
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DANIELLA ARAUJO DE OLIVEIRA
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ANNA MYRNA JAGUARIBE DE LIMA
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LAISA LIANE PAINEIRAS DOMINGOS
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Data: Dec 28, 2022
Ata de defesa assinada:
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Show Abstract
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The multisystemic infection caused by the New Coronavirus-19 (nCoV-19) causes consequences beyond the acute phase and respiratory symptoms, often observed in the first cases of infection. The identification of persistent sequelae in survivors of the New Coronavirus-19 Disease (COVID-19) has led to an increase in demand for rehabilitation services and has highlighted the need for a functional recovery intervention that is safe and well tolerated for this population. Whole Body Vibration (WBV) is an alternative strategy to conventional rehabilitation programs that has been studied in several people. The aim of this study was to evaluate the effectiveness of a whole-body vibration program on the risk of falls, balance, mobility and heart rate variability (HRV) in patients affected by moderate or severe forms of COVID-19. This is a randomized clinical trial approved by the Research Ethics Committee and the National Research Ethics Committee (CAAE 50633321.0.0000.5208, opinion nº 5.007.272), respecting all the norms of Resolution 466/12 of the National Health Council and registered in the Brazilian Clinical Trial Registry (ReBEC) (RBR-10c2pb73). Patients affected by COVID-19 who required hospitalization in a ward or ICU, discharged at least 4 months before the start of training, of both sexes, aged between 18 and 70 years were included in the research. The sample consisted of 13 patients. The study's primary endpoints were risk of falls, mobility and balance, and heart rate variability in its time and frequency domains. The normality and homogeneity of the sample were verified, respectively, using the Shapiro-Wilk and Levene tests. For comparison between the groups, the Anova test for repeated measures or the Kruskall-Wallis test were used for the risk of falls, mobility and balance and heart rate variability (HRV), based on time variations (pre and post) and intervention (Sham, IVC 4mm and IVC 2mm), followed by Tukey's or Nemenyi's post-hoc test. Statistical analysis was performed using the SPSS program, version 20.0. There was analysis by intention to treat in the groups where the loss was greater than 20%. Patients were allocated into the control group (G Sham, n=4), the 4 mm IVC group (G 4mm, n = 5) and the 2mm IVC group (G 2mm, n=4). Training with WBV at 2mm and 4mm amplitude resulted in a reduction in the risk of falls when compared to Sham (p= 0.023), with a large effect size of 0.530. No changes were observed for mobility and balance outcomes (p= 0.127) or for any of the HRV variables (p= 0.386). Whole-body vibration training was a safe and well-tolerated therapeutic modality by patients after 4 months of the acute phase of COVID-19. In addition, the perception of improvement in global status was satisfactory even in patients allocated to the Sham group. Adverse reactions such as mild itching in lower limbs and post-intervention muscle pain, which regressed within 24 hours, were observed in the studied population. Considering these findings, in order to strengthen the evidence regarding WBV training in post-COVID patients, this study will remain ongoing.
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